Alfonso Calderon is originally from Houston, Texas. He earned his associate's degree in kinesiology from Laredo College, his bachelor's degree in fitness and sports from Texas A&M International University, his Master of Education from the University of Houston-Victoria, and his Master of Science from the University of Cincinnati. He lives in Lavon, Texas with his family.

Alfonso currently works as an administrator at the Garland Independent School District, where he previously worked as an inclusion teacher and varsity football and head boy track coach. He previously worked as a teacher, assistant athletic director, and campus athletic coordinator at the United Independent School District and a teacher and coach at the Fort Bend Independent School District,

Alfonso's campaign for trustee with the Community Independent School District in Texas is his first run for public office.