Clayton Watson is from Atlanta, Georgia. He earned a bachelor's degree in human resource management from Georgia Southwestern State University. He lives on St. Simons Island, Georgia, with his wife, Leigh.

Clayton currently serves as the vice-chairman of the Glynn County Commission, representing District 2. He was elected in 2022 and is serving his first term.

Clayton currently works as senior vice president at Providence Care, a healthcare company. He previously founded Coastal Hospice of Georgia, a hospice care provider, and worked as vice president of operations at Phoenix Senior Living, a senior care company. He also worked as a regional vice president of operations for the Southeast and Mid-Atlantic at Medical Home Team, an area executive director at Gentiva Health Services, an area manager at Lincare Holdings, and at Apria Healthcare.