Denia graduated from Lakeview Fort Oglethorpe High School. She and her husband have two adult sons. Denis serves as the chairperson of Northwest Georgia Regional Educational Agency, chairperson of Catoosa Family Collaborative, member of the North Georgia Electric Membership Corporation Board of Directors, member of the Communities In Schools Board of Directors, a Partnership 2000 Board Member, and a member of the College and Career Academy Board of Directors.

Denia served as the superintendent of Catoosa Schools for 17 years until retiring in 2022. Previously, she was a teacher, assistant principal, and principal at Graysville Elementary School.

Denia Reese's campaign for Catoosa County Board of Education Member is her first entry into politics.